Magnesium for Your Brain

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The Pure TheraPro Team

The Pure TheraPro Education Team is comprised of researchers from diverse backgrounds including nutrition, functional medicine, fitness, supplement formulation & food science. All articles have been reviewed for content, accuracy, and compliance by a holistic integrative nutritionist certified by an accredited institution.
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COVID-19 and related global events have escalated daily incidences of stress for Americans, according to a Gallup poll. Stress has risen 14 percentage points to 60% compared to 2019. Those reporting they experienced daily enjoyment have declined by 20 percentage points. 

Magnesium is a mineral that helps with stress, anxiety, muscle aches and pains, insomnia and relaxing the body, however, many people are magnesium deficient. When stress is in overload, the body’s critical needs for magnesium increase, tapping into your natural stores. Although the current Recommended Daily Allowance for magnesium is between 300-420 mg/day, it is believed that over 50% of Americans are receiving less than that, and as a result, suffering the consequences. 

Aside from helping with sleep and anxiety, magnesium protects your heart and bones; a magnesium deficiency is linked with higher incidence of cardiovascular events and bone-related conditions such as osteoporosis. It may also cause neurological disorders, mental illness, seizures, traumatic brain injury and conditions such as Alzheimer’s and Parkinson’s disease. 



This might scare you into getting your blood work done immediately. But wait! The issue with testing magnesium levels is that only 1% of the body’s magnesium is stored in blood serum--the other 99% is housed in your bones and soft tissues--which means it’s pretty tough to assess your actual magnesium levels. 

Various forms of magnesium help with different issues. For example, magnesium oxide can help with frequent headaches, however, it is not a bioavailable form for raising levels. Magnesium citrate can be used to relieve constipation, although it can be harsh on the digestive tract with long-term use. Magnesium glycinate helps relax muscles and promote better sleep; magnesium malate binds to aluminum in the body and helps detoxify on a cellular level. Magnesium L-threonate is a form of magnesium that supports cognitive function and improved memory. 

Patented magnesium L-threonate, Magtein, is able to cross the blood brain barrier, according to studies. It has proven abilities to enhance synaptic density and neuroplasticity, particularly in areas of the brain that are responsible for experiencing fear and anxiety. Other studies indicate that Magtein helps the brain age backwards, taking the brain back as much as nine years!  

Magnesium is responsible for various enzymatic reactions in the brain. Since magnesium L-threonate crosses the blood brain barrier, this form of magnesium helps the synapses form connections that allow nerve cells to communicate more effectively. The result is visible to us as fewer memory issues, greater alertness, easier learning and cognitive function. It is believed that as we age, communication between synapses declines. Since magnesium is needed to elicit the activity of more than 300 enzymes, it makes sense that its ability to be utilized more effectively by the brain enhances cognitive ability. 

Aside from mental clarity and increased cognitive function, magnesium L-threonate can also help reduce stress and anxiety and chronic nerve pain, according to research. These findings are promising for those with traumatic injury and chronic pain as well as people with mental health issues, such as PTSD and generalized anxiety disorder. 

Because of its ability to cross the blood brain barrier, magnesium L-threonate is a superior form of magnesium. Studies are pointing to the importance of magnesium for optimum brain function. Magnesium in the brain helps regulate calcium ion movement in nerve calcium channels, which keeps nitric oxide in check. If one was to experience magnesium deficiency, damage to brain and nerve cells might occur, resulting in mental health issues, such as depression and anxiety, memory loss, impaired cognition, seizures and other serious issues. Magnesium L-threonate may help prevent neurological issues as well as repair damage with ongoing supplementation.  




Our Brain MagX contains evidence-based ingredients in our highly bioavailable powdered form to help support cognitive function. These ingredients include Magtein (Magnesium L-Threonate), Xerenoos Citicoline and Huperzine A.  

Magtein™ (Magnesium L-Threonate) is the ONLY form of magnesium proven in animal studies to cross the blood-brain barrier and effectively elevate magnesium levels in the BRAIN, which leads to enhanced learning abilities, improved working memory, and better short- and long-term memory. 

Citicoline, particularly the patented ingredient Xerenoos, is backed by over 100 clinical studies demonstrating benefits in a variety of cognitive disorders including Traumatic Brain Injury, stroke, memory loss/dementia, cerebral insufficiency and ADHD behaviors. 

Xerenoos helped the brain to regenerate and promote tissue healing as well as limit brain damage if given within 12 hours of the event. A 1986 study (Lozano et al) of 2067 patients with neuropsychiatric issues given citicoline supplementation over a two-month period demonstrated a 71% reduction in memory deficits. Citicoline supplementation also demonstrated improvement in attention, increased energy to the brain, greater propensity to formulate new brain cells and a reduction in ADHD impulsiveness.

A 2012 placebo-controlled study published in Food and Nutrition Sciences demonstrated the effects of citicoline supplementation in 60 women aged 40-60, given 250 mg citicoline, 500 mg citicoline or placebo over 28 days. Results showed that both citicoline groups performed better on cognitive tasks than the placebo group. In addition, the 500 mg group made significantly fewer cognitive errors than the 250 mg group.



A study (Eberhardt and Schurmann) of 89 patients looked at citicoline supplementation effects on cerebral insufficiency. This double-blind, placebo- controlled crossover study showed significant memory improvements with citicoline.

Huperzine A also has clinical evidence in improving memory and acetylcholine signaling. In a study of teenagers a small dose of Huperzine A (50 mcg) taken 2x daily for 4 weeks improved several aspects of memory and learning performance.

Huperzine A has also received significant attention for supporting memory and cognitive performance during aging. Acetylcholine is a neurotransmitter and neuromodulator (i.e., a messenger molecule released by nerve cells to signal and regulate other nerve cells). It plays important roles in cognitive function, most notably, in the neural mechanisms of memory. In addition to this memory function, acetylcholine is involved in supporting alertness, attention, and learning.  One of Huperzine A’s most recognized biological actions is its involvement in acetylcholine signaling. Huperzine A has improved acetylcholine levels in animal and human studies and influences cholinesterase enzyme activity. The net effect is an increase in acetylcholine. This involvement with acetylcholine signaling might explain its reported benefits on memory and cognition.

Huperzine A might offer other benefits. It has a reputation for increasing REM sleep (dreaming stage of sleep) and lucid dreaming —this reputational effect has not been studied but would presumably be related to acetylcholine. The compound also has some neuroprotective qualities which are important for maintaining a healthy brain.



To help maintain optimum levels of systemic magnesium, be sure you are supplementing with a bioavailable form of magnesium. 

Our Optimum Magnesium can help! Our formulation contains: 

✔ Magnesium Lysyl Glycinate Chelate, a mineral amino acid chelate delivers a complex with higher absorption rates. Since the body can efficiently absorb dipeptides (two amino acids linked together), Albion’s TRAACS magnesium lysyl glycinate is an optimum delivery system for magnesium. Albion TRAACS patented mineral amino acid chelates are resistant to competitive minerals, do not lessen the effectiveness of vitamins, and pose a lower risk of overdosing.

✔ Di-Magnesium Malate, also within Optimum Magnesium, contains 69% malate (malic acid). Malic acid is utilized because it enhances magnesiumMagnesium and malate play crucial roles in energy production under aerobic conditions or when decreased oxygen levels are present. Malic acid is known to show protective benefits by binding aluminum.

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