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Discover BioActive B12 Full-Spectrum

***Introducing our new and improved BioActive Vitamin B12™!

1) As of 9/12/2023, Pure Thera's newly reformulated BioActive B12 is a STRONGER daily dose (5 drops = 5,000mcg of Vitamin B12 daily).

2) Thanks to our sophisticated formulation utilizing organic vegetable glycerin, we were able to remove the natural potassium sorbate preservative from the formula.

3) While the glass bottle is now smaller and the total number of of servings has been reduced, because the formula is now stronger (5,000mcg) you pay a nearly identical amount per microgram of B12. 

Please keep in mind when comparing our practitioner-recommended formulas to competitors’ that, here at Pure TheraPro, we are a China-free supplement brand. This means that we must go to great lengths and expense to source quality ingredients from reputable suppliers outside of China. Purity is our priority.

BioActive B12 "Full Spectrum" - is a high-quality VEGAN Vitamin B12 complex utilizing the three most important bioavailable forms of B12.

This advanced formula includes highly desirable ingredient forms that do not require conversion in the liver in order to be available for use by your cells.

  • METHYLCOBALAMIN -- Biologically Active Form: Utilizing third-party-tested Methylcobalamin with exceptional purity, our Methylcobalamin is an active, pre-methylated form of Vitamin B12 that is immediately able to be used by your body's cells and does not require extra work by vital methyl donors or your liver to be made bioavailable.

  • ADENOSYLCOBALAMIN -- Mitochondrial Form: An active "coenzyme" form of B12 and is utilized directly in B12-dependent enzyme reactions in the body.

  • HYDROXOCOBALAMIN -- Protector Form: Readily converts to Methylcobalamin and has a unique role in supporting detoxification processes.

  • From your blood cells to your nerves and down to your DNA, Vitamin B12 is a critical vitamin for the health of your body.

    We've carefully formulated this highly bioavailable, vegan BioActive B12 to include ALL 3 bioavailable forms of B12. Bioactive simply means that the precious B12 has already been converted into a form that your body can utilize immediately. 

    With these specialized bioactive forms, the B12 does not need to be converted in order to be available for use by your cells (conversion can be especially problematic for people with MTHFR issues such as MTR, MTRR, COMT as well as other gene defects and mutations).

    Did you know that both vegan and non-vegan individuals commonly suffer from B12 insufficiency? If you’re omnivorous, you may get some B12 from meats, dairy and eggs (often not nearly enough as we no longer consume organ meats); however vegetarians and vegans have a much more difficult time.

    If you’re a strict vegan, studies have confirmed that you’re likely to be insufficient in B12, unless you’re supplementing regularly. While rates of B12 insufficiency are much higher in vegetarians and vegans than in omnivores, that doesn’t mean it’s rare in omnivores. Approximately 1 in 20 omnivores are B12 insufficient. 

    B12 deficiency is also more common in people with gut problems because that often decreases intestinal absorption (including taking OTC drugs which block stomach acid).

    Older adults are also at risk as stomach acid levels decline as we age, which makes it difficult to cleave the Vitamin B12 from its protein bound form in food.

    The consequences of Vitamin B12 insufficiency are extremely serious and sometimes irreversible (nerve damage for example).

    Vitamin B12 is water soluble - our bodies are unable to store it for very long. Ultimately, it's very important that you are getting enough B12 in your diet every day - and the easiest, most bio-available method is to take this supplement consistently.

    Methylcobalamin - Assists methylation, supports brain & nerve health, circulatory & immune systems, and normal homocysteine levels.

    Adenosylcobalamin - Supports muscle recovery, mitochondrial structure and function, as well as the structure and function of the delicate myelin sheath.

    Hydroxocobalamin is a precursor form of Vitamin B12 converted in the body to both Methylcobalamin and Adenosylcobalamin. This form of B12 helps support mood, an overall sense of well being, energy production, clear thinking and detoxification.

    Manufactured in the USA in an NSF and GMP-certified facility, for guaranteed quality and potency. This supplement is lab tested to ensure the highest quality, potency and purity of each batch.

    Customer Reviews

    Based on 29 reviews
    Cynthia Seagraves-Daigre
    Love Pure TheraRx

    I appreciate the quality of this product. If you're going to take supplements, quality is key and their products fit the bill. They are easy to use. There is no bad taste and I've not noticed a problem with digesting them. Keep up the good work

    Estelle Koch
    Great tasting and Most effective B12 product!

    BioActive B12 Full-Spectrum is awesome B12 product I have never used before! It really works well for me to improve my anemia symptoms. I'll keep using it continuously! I deeply appreciate Pure TheraPro Rx.

    Lady Luminaria
    Using for over a Year

    My favorite B12 supplements, it actually helped with my lab results.
    I'll definitely keep buying this and highly recommend it!

    Dinky Deb
    No real taste to it

    It doesn't really a taste or flavor, just slightly sweet, I like that. It's easy to use. I store mine in the refrigerator and take it when I remember. I need to think of a way to remember to take it consistently - I don't notice it in the refrigerator for days.


    If u are seriously considering raising your B/12 levels, then you have found the right product!!
    My Dr runs labs on me, every 3 months- due to some health issues related to nutritional deficiencies.
    Before using this product my b12 level was 529.
    When I went back, my levels were a little over 1400.
    I will attest to this product working~
    I'm a very cautious person when it comes to trying new products, & I am definitely not one for spending my money on stuff that don't deliver, but as I've said, this is the real deal!!
    If you have a problem in ANY area & have additional questions, I know that you will find these professionals readily available & willing to assist you, as I did.
    I also had an issue with my D3,
    trying to get it up from 15 into the normal range, which several Drs. had tried unsuccessfully for years to raise my levels. Therefore, when the D3/K2 wasn't doing the trick, I just chalked it up to the product not delivering and almost gave up on even ordering it ever again.
    But, I thought... I am going to call PureTheraPro Rx, and see if they have any answers for me
    As to why their product isnt raising my levels & im so glad that I did! I was so happy to learn that, they did indeed have a solution for me.
    And when I added the missing "Boron" component, it went up & now I am happy to say that I am in the normal range (maybe a bit higher, bc I refuse to stop taking My Vitamin D3, especially with us going into the winter months.
    The team at PureTheraproRX, have
    been extremely kind & helpful to me in so many ways.
    Thank You all so very much & the Tips you give regarding products & how they work is very much appreciated.
    [Sorry Everyone- about my review being so lengthy].

    Frequently Asked Questions

    Vitamin B12 as MecobalActive® Methylcobalamin, Adenosylcobalmin & Hydroxocobalamin

    Other Ingredients
    Triple-Distilled Water, USDA Certified Organic Kosher Vegetable Glycerin, Natural Potassium Sorbate Derived from Mountain Ash Tree Berries, Natural Citric Acid Derived from Citrus Fruits

    Fillers, wheat, gluten, yeast, soy protein, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, artificial colors, artificial sweeteners, or artificial preservatives.

    All Pure TheraPro Rx Formulas Meet or Exceed cGMP Quality Standards. This product is manufactured in the USA in a FDA inspected, NSF and GMP-certified facility for guaranteed quality and potency.

    BioActive B12 Supports Nervous System and Brain Health

    BioActive B12 is a high quality vegan B12 complex utilizing three bioavailable forms of this key vitamin. These forms require no conversion in the liver in order to be used by your cells. As a pure and potent supplement, BioActive B12 provides maximum absorption with a mild taste that is easy on the palate.  

    Clinically Effective Formula

    Vitamin B12 is a critical vitamin for the health of our bodies. We’ve carefully formulated this highly bioavailable Vegan BioActive B12 to include all three forms of B12, including methylcobalamin, adenosylcobalamin, and hydroxocobalamin. BioActive means that B12 has already been converted into a form that your body can utilize immediately. With these specialized bioactie forms, the B12 does not need to be converted in order to be available for use by your cells. 

    Uncompromising Quality

    Watch out! Most Vitamin B12 supplements contain cheap and ineffective Chinese cyanocobalamin. This undesirable form is not easily used by your body and must be converted in the liver via methylation; a serious problem for the millions of Americans with MTHFR mutations. And because it is derived from coal tar, it is also often tainted with unwanted toxins that can harm your body. Pure Thera’s BioActive B12 is formulated with the three best forms of Vitamin B12 in the world, and these forms are easily absorbed and utilized by your body and brain.

    Purity Is Our Priority

    Pure Thera provides supplement solutions to ensure your body gets the micronutrients necessary to support total-body health and vitality. Pure TheraPro supplements do not contain any fillers such as rice flour, corn starch, or wood pulp fibers like cellulose. Our manufacturing facility adheres to strict NSF/cGMP (Current Good Manufacturing Practices) guidelines.

    A comprehensive system

    Many of our biological systems are simultaneously impacted by lifestyle, diet and supplementation. When you provide an optimized environment for nutrients, they will work synergistically, resulting in greater outcomes. We recommend several complementary products based on supporting clinical study data and customer feedback.