Why Everyone Over 40 Should Be Taking Methylated Multivitamins

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The Pure TheraPro Team

The Pure TheraPro Education Team is comprised of researchers from diverse backgrounds including nutrition, functional medicine, fitness, supplement formulation & food science. All articles have been reviewed for content, accuracy, and compliance by a holistic integrative nutritionist certified by an accredited institution.
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As we enter our 40s and beyond, our bodies begin to experience a range of changes that can influence our overall health and well-being. One of the most important factors in maintaining good health during this time is understanding methylation and the nutrients that support this vital process.

So, what exactly is methylation? It’s a key biochemical reaction that plays a crucial role in several essential functions in our bodies, including DNA synthesis, detoxification, and the regulation of inflammation. Essentially, methylation helps our cells function optimally and supports our body's ability to heal and repair itself.

In this article, we will dive into the importance of methylated multivitamins for those over 40. We’ll discuss how these specialized vitamins can boost your health, enhance nutrient absorption, and ultimately support your overall well-being. For a comprehensive guide on this topic, be sure to check out our recent article here. In it, we also discuss Joe Rogan and Gary Brecka’s insights on the importance of methylated vitamins and why they are essential for our health.

Importance of Nutrients In Aging: Why Is Methylation Critical?

Aging is a natural process accompanied by a gradual decline in various bodily functions, including nutrient absorption and metabolism. As we age, our bodies become less efficient at absorbing essential vitamins and minerals, which can lead to nutrient deficiencies. While we cover this more in depth later in this article, this decline can be attributed to several factors, including changes in digestion, hormonal fluctuations, and alterations in the gut microbiome.

Why Methylation Matters

Methylation is a biochemical process that involves the addition of a methyl group (CH₃) to various substrates in the body, playing a critical role in gene expression, detoxification, and cellular repair. Proper methylation is essential for maintaining optimal health, particularly in older adults. Methylation impacts how the body processes nutrients, regulates neurotransmitters, and supports the immune system. 

As we age, the need for efficient methylation becomes increasingly important to counteract age-related changes in metabolism and to promote overall health. For individuals over 40, methylated vitamins are particularly beneficial because they can bypass some metabolic pathways that may become less efficient with age.

What Are Methylated Vitamins?

Methylated vitamins are forms of vitamins that have undergone a methylation process, resulting in improved absorption and utilization. This alteration allows the body to access the nutrients more efficiently, which is especially important for older adults who may have decreased metabolic capacity.

Another consideration for taking methylated multivitamins is if you have methylation problems, methylated multivitamins stand out because they include vitamins in a form your body can use right away. The way that up to 40% of people methylate can affect how well their systems can utilize particular vitamins.

Key Methylated Nutrients

Methylated B Vitamins (B12, Folate)

Among the most important methylated vitamins are the B vitamins, particularly methylcobalamin (B12) and L-methylfolate (folate). These vitamins are essential for various bodily functions, including DNA synthesis, red blood cell formation, and neurological health. Methylcobalamin is the active form of B12 that the body can use directly, while L-methylfolate is the bioactive form of folate that supports methylation processes. Supplementing with these forms can help individuals over 40 maintain optimal levels of these critical nutrients.

Those with the MTHFR gene mutation often struggle to process certain nutrients, especially folate. Methylated vitamins, like methylfolate, are already in a form that the body can easily use. If you have this genetic mutation, taking methylated multivitamins can help ensure you get the nutrients necessary for optimal health.

Changes in Absorption After Age 40

As we age, several physiological changes can hinder nutrient absorption. The efficiency of the digestive system can decline, leading to decreased absorption of essential vitamins and minerals. This decline can be attributed to factors such as reduced gastric acid production, slower intestinal motility, and changes in gut microbiota, all of which can impact nutrient bioavailability.

One significant change that occurs with aging is a decrease in stomach acid production. Gastric acid is essential for the digestion and absorption of various nutrients, including vitamin B12, calcium, and magnesium. Reduced stomach acid can impair the absorption of these nutrients, leading to potential deficiencies. Additionally, enzyme production in the pancreas may decline, further complicating the digestion of food and absorption of nutrients.

Reduced Nutrient Quantities in Soil

One major challenge to nutrient absorption is the decline in the nutrient content of our soil, primarily due to modern agricultural practices and environmental issues. Over the years, industrial farming methods, such as the heavy use of fertilizers and pesticides, have negatively impacted soil health. These practices can lead to soil depletion, meaning it loses its ability to supply essential nutrients to plants.

Recent research highlights this concerning trend. For example, a study published in the Journal of the American College of Nutrition found that the mineral content of fruits and vegetables has dropped by as much as 40% since the 1950s. This decline in nutrient density means that even if you eat a balanced diet rich in fruits and vegetables, you might not be getting all the essential nutrients your body needs. 

Another study conducted by researchers at the University of Texas revealed similar findings, noting that fruits and vegetables grown in the United States have become less nutrient-dense. The research pointed out that the increased reliance on high-yield crop varieties has prioritized quantity over quality, leading to less nutrient uptake from the soil.

This situation is particularly important for individuals over 40, as nutrient absorption naturally declines with age. As our bodies become less efficient at extracting and utilizing nutrients from food, the need for supplementation grows. High-quality methylated multivitamins can play a crucial role in this context. These multivitamins contain active forms of essential vitamins and minerals that the body can readily absorb and use, helping to bridge the gap between what we consume and what our bodies actually need.

Click here to check our latest article on the benefits of methylated vitamins and how nutrient depletion from modern agriculture, processed foods, and imbalanced diets can impact your health. 

The Role of Methylation in Aging

The methylation cycle is a key process in our bodies that involves transferring small chemical groups called methyl groups (which consist of one carbon atom and three hydrogen atoms) to different molecules. Think of methyl groups as tiny helpers that assist various tasks in our body.

This cycle is essential for many important functions, including:

  • DNA Synthesis: Methylation plays a role in creating and repairing our DNA, the genetic blueprint that contains instructions for how our bodies operate. Proper methylation helps ensure our DNA stays healthy and functions correctly.
  • Neurotransmitter Production: Neurotransmitters are chemicals in our brain that help transmit signals between nerve cells. Methylation is involved in producing important neurotransmitters like serotonin, which affects mood, and dopamine, which influences motivation and pleasure.
  • Detoxification: Our bodies are constantly exposed to toxins from food, the environment, and even our own metabolism. Methylation helps our bodies process and eliminate these harmful substances, making it a vital part of our detoxification system.

A properly working methylation cycle supports cellular repair, which helps keep our tissues and organs healthy. It also helps reduce the risk of age-related diseases, such as heart disease, cognitive decline, and other autoimmune diseases.

In simple terms, the methylation cycle is like a factory in our body that produces crucial components needed for our health. When it runs smoothly, it helps us stay healthy and energetic as we get older. However, if the cycle is disrupted, it can lead to various health issues, emphasizing the importance of supporting this process with the right nutrients.

Consequences of Poor Methylation

  • Increased Inflammation: Methylation plays a role in controlling inflammation in the body. When methylation is poor, it can lead to higher levels of inflammation, which is linked to various health issues. Chronic inflammation can contribute to discomfort and is associated with conditions like joint disorders and other inflammatory diseases.
  • Impaired Detoxification: Our bodies are constantly exposed to toxins from food, the environment, and even from natural processes in our body. Methylation is essential for helping the liver process and eliminate these toxins. When methylation is not functioning optimally, detoxification can be less effective, potentially allowing harmful substances to build up in the body.
  • Higher Risk of Chronic Diseases: Poor methylation has been associated with an increased risk of chronic diseases. This includes cardiovascular diseases, which affect the heart and blood vessels, as well as certain types of cancer. While these conditions can arise from multiple factors, maintaining healthy methylation is important for reducing potential risks.

Benefits of Methylated Multivitamins for Detoxification and Supporting Balanced Inflammation

Supporting Detoxification Pathways

Methylated multivitamins play a critical role in supporting the body’s detoxification pathways. They help enhance liver function by providing the necessary nutrients that facilitate the detoxification process. For instance, methylated B vitamins are involved in the synthesis of glutathione, a powerful antioxidant that protects cells from oxidative stress and supports detoxification.

Supporting a Healthy Inflammatory Response

Chronic inflammation is a common issue as we age and can contribute to a wide range of conditions, including joint, heart, brain health issues. Methylated vitamins help regulate inflammatory responses in the body, promoting a healthier balance. For example, methylated B vitamins play a role in the production of neurotransmitters that regulate inflammation, helping to maintain overall health and well-being.

Role in Supporting Cellular Repair and Energy Production

Methylated multivitamins also support cellular repair processes and energy production. They provide essential nutrients that are crucial for mitochondrial function, which is responsible for producing energy in our cells. By ensuring adequate levels of these nutrients, individuals over 40 can help maintain their energy levels and support overall cellular health.

Our Favorite Methylated Supplement

Grasping the distinctions between methylated and regular multivitamins, and identifying which type aligns best with your individual health needs, can greatly impact your overall well-being. It’s not merely about addressing nutritional deficiencies; it’s about doing so in a manner that acknowledges and caters to your body’s specific requirements.

Methyl Multi™ Without Iron is a comprehensive methylated vitamin and mineral blend made from the absolute highest-quality ingredients with zero fillers or Chinese ingredients. 

This advanced formula features vegan-friendly, hypoallergenic, and meticulously-researched micronutrients, including patented Quatrefolic® Folate (5-MTHF) for maximum MTHFR support, and patented Albion® TRAACS® chelated mineral complexes for maximum absorption and bioavailability.

Methyl Multi™ is the ultimate multivitamin to support total-body wellness and optimum vitality.

 

References

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Hoffman, A. R., et al. (2011). Folate and methylation: Implications for health. Clinical Reviews in Allergy & Immunology, 40(2), 109-115. https://doi.org/10.1007/s12016-010-8242-5

Goyal, A., et al. (2022). MTHFR gene polymorphisms and their association with health outcomes: A comprehensive review. Journal of Clinical Medicine, 11(3), 767. https://doi.org/10.3390/jcm11030767

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Nair, A. K., et al. (2016). The role of B vitamins in methylation and disease. Nutrition Research Reviews, 29(1), 1-13. https://doi.org/10.1017/S0954422415000212

McCaddon, A., et al. (2001). The role of vitamins in the prevention of cognitive decline. Alzheimer’s & Dementia, 1(1), 69-76. https://doi.org/10.1016/j.jalz.2005.05.005

Pérez-López, F. R., et al. (2012). Nutritional deficiencies and their implications for health: The case for methylated vitamins. Menopause: The Journal of The North American Menopause Society, 19(4), 453-458. https://doi.org/10.1097/gme.0b013e3182456f30

Shin, J. Y., & Kim, K. H. (2019). The relationship between diet, methylation, and health: Implications for future research. Nutrients, 11(4), 828. https://doi.org/10.3390/nu1104082