As you age, one of the most common complaints is the noticeable decline in energy levels. People over 40 often experience chronic fatigue, a lack of vitality, and a struggle to maintain the energy they once had in their younger years. This decline can impact both mental and physical health, leading to diminished productivity and a reduced quality of life. While age-related fatigue is a natural process, many are unaware of the specific causes behind it and the potential solutions to combat it.
One of the key factors contributing to this decline in energy is your body’s reduced ability to produce certain essential compounds. Two of these compounds—Pyrroloquinoline Quinone (PQQ) and Coenzyme Q10 (CoQ10)—play a vital role in cellular energy production. Over time, your body’s natural production of CoQ10 decreases, which can negatively affect mitochondrial function and energy levels. This is where supplementation can make a profound difference.
PQQ and CoQ10 work at the cellular level to support the mitochondria, often referred to as the "powerhouse" of the cell, where energy (ATP) is produced. Without adequate levels of these compounds, your cells struggle to maintain efficient energy production, leading to feelings of fatigue and sluggishness. It is not just about fighting fatigue—it’s about reclaiming your vitality and living life to the fullest.
Why Energy Declines After 40?
CoQ10 is integral to the process of ATP production within the mitochondria, which serve as the energy factories of the cell. When CoQ10 levels drop, the efficiency of these mitochondria diminishes, resulting in lower energy output. This manifests as fatigue, slower recovery times, and a general lack of vitality—common complaints for adults over 40.
The reduction in CoQ10 is part of the natural aging process. Studies have shown that CoQ10 levels peak in your twenties and gradually decrease with each passing decade. By the time you reach your forties and beyond, CoQ10 production can decline significantly, contributing to age-related fatigue. While it’s natural to experience some level of reduced energy as you age, this decrease can be exacerbated by lifestyle factors such as poor diet, lack of exercise, and increased stress.
Furthermore, the energy deficit caused by CoQ10 decline is more pronounced in the elderly, who often struggle with persistent fatigue. This exhaustion can make daily activities more challenging, reducing overall quality of life. For many older adults, the underlying cause of their chronic fatigue often goes unrecognized, leading to misconceptions about aging being synonymous with feeling perpetually tired.
Causes of Sudden Fatigue in Older Adults: Exploring Health Factors
Other factors like high blood pressure can also contribute to sudden and extreme fatigue in elderly individuals. When your blood pressure is elevated, your heart must work harder to pump blood, putting additional strain on your body’s energy reserves. This combination of reduced CoQ10 levels and cardiovascular strain creates a double burden, leaving many older adults struggling to maintain the energy they need to function optimally.
CoQ10, an essential enzyme for cellular energy, begins to decline in the 40s, and by the age of 50, levels can drop by up to 30% compared to their peak in earlier years. This reduction can lead to feelings of tiredness and decreased energy.
A CoQ10 deficiency doesn't just affect your energy—it can also impact your heart health, as your heart relies heavily on constant energy production to function properly. Research suggests that lower CoQ10 levels are linked to cardiovascular issues and a slower recovery from exercise. This is particularly relevant for individuals in their 40s and beyond, as supporting heart health becomes increasingly important as you age.
Nutrient deficiencies, particularly in vitamins like B12, D3, and iron, can cause extreme fatigue. These nutrients are essential for energy metabolism and red blood cell production. Older adults are more likely to have nutrient deficiencies due to reduced absorption efficiency, poor diet, or certain medications. Ensuring adequate intake of these vitamins, either through diet or supplementation, can help correct any deficiencies you may have, and also restore energy.
Certain chronic conditions, such as diabetes, thyroid disorders, and depression, can also contribute to fatigue. Managing these conditions with appropriate medical care, combined with energy-boosting strategies, can significantly improve energy levels.
Role of CoQ10 in Energy Production
The highest concentrations of CoQ10 are found in your organs with high energy demands, such as the heart, liver, and kidneys. Without sufficient CoQ10, the body’s ability to produce ATP decreases, leading to a decline in overall energy levels, fatigue, and diminished cellular function.
At the core of energy production is the mitochondria, often called the “powerhouses” of the cell. Inside these mitochondria, CoQ10 facilitates the transfer of electrons during cellular respiration, which is the process that converts the food we eat into usable energy. When CoQ10 levels are sufficient, this process operates efficiently, keeping cells energized and healthy. However, as CoQ10 production declines with age, mitochondrial function is compromised, leading to slower energy production, which is why many adults over 40 feel more fatigued and less resilient.
Incorporating CoQ10 into a daily supplement routine can make a significant difference in energy production and overall well-being, particularly for those experiencing age-related energy decline.You can continue reading about CoQ10 in our latest article and find out more about its benefits here.
PQQ: The Unsung Hero for Cellular Energy
PQQ is a powerful compound that has gained attention for its ability to boost energy levels, especially when combined with CoQ10. While CoQ10 focuses on optimizing the function of existing mitochondria, PQQ works to stimulate the growth of new mitochondria in cells—a process known as mitochondrial biogenesis. This dual approach of improving mitochondrial efficiency and increasing their numbers makes PQQ and CoQ10 a potent combination for combating age-related energy decline.
Mitochondria are critical for producing the energy cells you need to function. PQQ plays a unique role supporting mitochondrial growth, improving the overall energy output of cells. This leads to increased stamina, better cognitive function, and improved cellular health.
What sets PQQ apart is its ability to protect your cells from oxidative stress, a major contributor to cellular aging. PQQ acts as an antioxidant, neutralizing harmful free radicals that can damage mitochondria and impair energy production. By reducing oxidative stress, PQQ not only enhances mitochondrial function but also supports overall cellular health, which is crucial for maintaining energy levels over time. This is why PQQ is often included in energy-boosting supplement regimens.
Additionally, PQQ has been shown to support brain function by enhancing nerve growth and protecting neurons. For older adults, this can mean sharper mental clarity and better memory, along with the physical energy boost provided by healthier mitochondria.
MicroActive CoQ10 vs Standard CoQ10:
While CoQ10 supplementation is a well-known solution for restoring energy and mitochondrial function, not all CoQ10 supplements are equally effective. Key differences include:
Bioavailability
One of the biggest challenges with standard CoQ10 supplements is their poor bioavailability, meaning your body absorbs only a fraction of the dose, limiting its effectiveness. This is because CoQ10 is fat-soluble and has a large molecular structure, making it difficult for the digestive system to absorb. To get the desired benefits, higher doses are often required, which can be inefficient and costly over time.
MicroActive® CoQ10 is a unique complex that contains highly bioavailable micronutrient forms that are universally absorbed much more effectively when compared to standard CoQ10 & PQQ alone. These combined ingredients are clinically-studied with results showing support for your brain and cognitive health, which offers a solution to these absorption challenges. Utilizing a patented, advanced absorption technology, MicroActive CoQ10 ensures that your body can absorb and use more of the supplement.
This form of CoQ10 is water-soluble and designed for sustained release, meaning it remains in the bloodstream longer and provides a steady supply of CoQ10 over time. MicroActive CoQ10 has 3 times the absorption of standard CoQ10, making it a far more effective option for those looking to boost their energy levels and support heart health.
Absorption
The key advantage of MicroActive CoQ10 lies in its ability to deliver consistent, long-lasting benefits. Standard CoQ10 supplements are absorbed in spikes, leading to fluctuations in energy levels as the compound is quickly metabolized and excreted. In contrast, MicroActive CoQ10’s sustained-release formula ensures that the body maintains steady CoQ10 levels throughout the day. This translates to more consistent energy, reduced fatigue, and better overall cellular function.
Additionally, the superior bioavailability of MicroActive CoQ10 means that smaller doses are required to achieve the same or greater effects compared to standard CoQ10 supplements. This makes MicroActive CoQ10 more cost-effective in the long run, as users can get better results with lower doses, while also minimizing potential digestive discomfort that may occur with higher doses of standard CoQ10.
Natural Ways to Boost Energy Levels in Older Adults
While PQQ and CoQ10 are highly effective supplements for improving energy levels and improving mitochondrial health, they work even better when combined with natural lifestyle changes that support overall energy production. Maintaining consistent energy levels as we age requires a holistic approach that addresses diet, exercise, sleep, and stress management.
1. Nutrient-Dense Diet: A balanced, nutrient-rich diet plays a crucial role in sustaining energy levels. Focus on foods that are high in vitamins and minerals, particularly those that support mitochondrial function, such as magnesium, B vitamins, and antioxidants. Leafy greens, nuts, seeds, whole grains, and lean proteins are excellent sources of these nutrients. Additionally, certain vitamins increase energy, such as B12 and D3, which help support metabolic processes and reduce fatigue. Vitamin B12 is found primarily in animal products such as meat (beef, chicken), fish (salmon, tuna), eggs, dairy (milk, cheese), and fortified cereals.
2. Regular Physical Activity: Exercise is one of the most effective ways to naturally boost energy. Regular physical activity, particularly aerobic exercises like walking, swimming, or cycling, increases blood flow and promotes the growth of new mitochondria. This improves the body’s ability to produce energy, leading to better endurance and reduced fatigue. Even moderate exercise can make a significant difference in how energized you feel throughout the day.
3. Adequate Sleep: Poor sleep quality or insufficient sleep is a leading cause of chronic fatigue. Aim for 7-9 hours of sleep per night to allow your body ample time to recover and regenerate. Establishing a regular sleep routine and creating a restful environment can improve the quality of your sleep, making it easier to wake up feeling refreshed and energized.
4. Stress Management: Chronic stress can drain your energy and lead to feelings of exhaustion. Incorporating stress-reduction techniques like meditation, deep breathing, or yoga can help regulate stress hormones and improve mental and physical energy levels. Addressing stress is especially important for older adults, as prolonged stress can exacerbate energy decline.
Pure Thera’s MicroActive CoQ10 with MicroPQQ + Shilajit – Sustained Energy and Healthy Aging
Pure Thera’s MicroActive CoQ10 with MicroPQQ + Shilajit has a scientifically advanced formula that delivers superior energy, cognitive, and mitochondrial support. Backed by over 10 human clinical studies, this patented CoQ10 form offers 3x better bioavailability than standard CoQ10, ensuring your body absorbs and utilizes the supplement more effectively. Unlike other CoQ10 products that depend on dietary fats for absorption, MicroActive CoQ10’s technology allows for sustained release over 24 hours, ensuring consistent energy throughout the day.
Clinical data shows that MicroActive CoQ10 doubles serum CoQ10 levels after just three weeks, with every subject in the study experiencing increased absorption—up to 370% better than regular CoQ10. This extended-release formula ensures that CoQ10 stays in your system longer, supporting mitochondrial health, brain function, and healthy aging.
In addition, MicroActive PQQ—another key ingredient—delivers 220% better absorption than regular PQQ, supporting nerve cell health, cognitive function, and even helping alleviate occasional stress. Its 9+ hour sustained release supports cerebral function and metabolism, making it a powerful ally for mental clarity and overall vitality.
The formula also features PrimaVie® Purified Shilajit, a potent adaptogen from the Himalayas used for centuries to promote healthy aging. This natural ingredient supports mitochondrial efficiency and energy production at the cellular level, helping you maintain focus and vitality throughout the day.
Manufactured in the USA in a GMP-certified facility, MicroActive CoQ10 combines pharmaceutical-grade ingredients with cutting-edge absorption technology to deliver unparalleled energy, brain function, and healthy aging support. Time to reclaim your vitality.
References:
Chowanadisai, W., Bauerly, K. A., Tchaparian, E., Wong, A., Cortopassi, G. A., & Rucker, R. B. (2010). Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1α expression. The Journal of Biological Chemistry, 285(1), 142-152. https://doi.org/10.1074/jbc.M109.030130
Hernández-Camacho, J. D., Bernier, M., López-Lluch, G., & Navas, P. (2018). Coenzyme Q10 supplementation in aging and disease. Frontiers in Physiology, 9, 44. https://doi.org/10.3389/fphys.2018.00044
Shults, C. W., Oakes, D., Kieburtz, K., Beal, M. F., Haas, R., Plumb, S., ... & Parkinson Study Group. (2002). Effects of coenzyme Q10 in early Parkinson disease: Evidence of slowing of the functional decline. Archives of Neurology, 59(10), 1541-1550. https://doi.org/10.1001/archneur.59.10.1541
Bentinger, M., Tekle, M., & Dallner, G. (2010). Coenzyme Q–biosynthesis and functions. Biochemical and Biophysical Research Communications, 396(1), 74-79. https://doi.org/10.1016/j.bbrc.2010.02.147