Understanding Chronic Kidney Disease

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The Pure TheraPro Team

The Pure TheraPro Education Team is comprised of researchers from diverse backgrounds including nutrition, functional medicine, fitness, supplement formulation & food science. All articles have been reviewed for content, accuracy, and compliance by a holistic integrative nutritionist certified by an accredited institution.
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Have you or a loved one dealt with kidney chronic health issues? Chronic Kidney Disease is a progressive and long-term condition characterized by the gradual loss of kidney function over time.

Our kidneys are remarkable organs that play a vital role in filtering waste products, excess fluids, and toxins from our bloodstream. When they become damaged or dysfunctional, waste accumulates in our bodies, leading to a range of health complications.

Unfortunately, CKD is often irreversible and can ultimately progress to end-stage renal disease (ESRD), where the kidneys are no longer able to perform their essential functions without medical intervention such as dialysis or transplantation.



Did you know that an estimated 37 million adults in the United States are living with CKD? Astonishingly, this accounts for approximately 15% of the adult population. The risk of developing CKD increases with age, with adults aged 65 and older being particularly vulnerable.

Among this older population, the prevalence of CKD rises significantly, affecting around 38% of individuals. It's important to recognize the impact of this condition on a substantial number of people.

Causes and Mechanisms of CKD
CKD can arise from various underlying causes, and understanding its mechanisms helps us grasp the complexities of this condition. The damage to the kidneys and their filtering units, called nephrons, occurs gradually and involves factors such as inflammation, oxidative stress, fibrosis, and immune system dysfunction. These factors combine to initiate and progress CKD over time.

The Culprits:

Diabetes: Diabetes Mellitus, especially Type 2 diabetes, poses a significant threat. Elevated blood sugar levels over prolonged periods can damage the blood vessels in the kidneys, impairing their filtration capabilities. Managing blood glucose levels diligently and undergoing regular monitoring are vital for people with diabetes to reduce the risk of developing CKD.

Hypertension (High Blood Pressure): Uncontrolled hypertension exerts excessive strain on the blood vessels in the kidneys, causing damage over time. Proper blood pressure management through lifestyle modifications, stress relief, targeted supplementation, and, if needed, medications and regular monitoring is crucial to prevent or slow down the progression of CKD.

Obesity: Obesity adds another layer of risk to kidney health. Excess body weight increases the likelihood of developing diabetes and hypertension, both of which contribute to kidney damage. Maintaining a healthy weight through a balanced diet and regular exercise can help mitigate the risk of CKD.

Cardiovascular Disease: Cardiovascular disease, including heart disease and stroke, shares a close connection with CKD. These conditions often coexist due to shared risk factors like diabetes, hypertension, and obesity. Managing these cardiovascular risk factors through lifestyle changes and appropriate medical interventions plays a critical role in reducing the risk of CKD. 



Genetics and Gender: Genetics and family history also play a part in CKD. If kidney disease runs in your family, you may have an increased risk of developing CKD. Age and gender contribute as well. As we grow older, our kidney function naturally declines, and men have a slightly higher risk compared to women. Advanced age is a risk factor for CKD, as kidney function naturally declines with age. The aging population and gender disparities highlight the need for increased awareness, early detection, and appropriate management strategies for CKD in our aging population.

Ethnicity and Race: Certain ethnic and racial groups have a higher prevalence of CKD and a greater risk of disease progression. African Americans, Hispanics, Native Americans, and Pacific Islanders are among the groups with higher rates of CKD.

Smoking and Substance Abuse: Smoking and substance abuse, including excessive alcohol consumption and illicit drug use, can contribute to the development and progression of CKD. These habits can damage blood vessels, impair kidney function, and exacerbate other risk factors such as hypertension. Quitting smoking and seeking support for substance abuse issues are essential steps in reducing the risk of CKD.

Other Contributing Factors: Additional factors that can increase the risk of CKD include urinary tract infections, kidney stones, urinary tract obstruction, systemic autoimmune diseases, and certain medications. It is important to address these conditions right away and manage these conditions under the guidance of healthcare professionals to minimize the impact on kidney health.

Symptoms and Diagnosis of Chronic Kidney Disease

In the early stages of CKD, symptoms may be subtle or absent. However, some individuals may experience symptoms such as fatigue, decreased appetite, increased thirst, changes in urine frequency or volume, and mild swelling in the extremities. These symptoms may be nonspecific and can be attributed to other causes, making early detection through regular screenings crucial.


As CKD progresses to more advanced stages, symptoms become more pronounced. These may include persistent fatigue, difficulty concentrating, insomnia, muscle cramps, itching, shortness of breath, nausea, vomiting, persistent hiccups, swelling in the legs and ankles (edema), and changes in urine color or frequency. Advanced CKD may also lead to complications such as anemia, bone disease, and cardiovascular problems.

Screening for CKD is particularly important for individuals with risk factors such as diabetes, hypertension, family history of kidney disease, or certain ethnic backgrounds.

Screening typically involves assessing kidney function through blood and urine tests. Regular monitoring allows for early detection and intervention, facilitating better management and improved outcomes for individuals at risk of or living with CKD.

Understanding the risk factors associated with CKD and recognizing the symptoms and diagnostic procedures aids in the early identification and management of the condition. By addressing these factors and promoting timely screenings, healthcare professionals can work together with individuals to prevent or slow the progression of CKD and improve the overall well-being of affected individuals.

Tips to Prevent it:

  •  Balanced Diet and Fluid Intake 

Eating a balanced diet plays a crucial role in kidney health. Consume a diet rich in organic fruits & vegetables, clean proteins, and healthy fats while limiting high-omega-6 vegetable oils (such as canola oil & cottonseed oil), and refined sugars. Additionally, maintaining proper hydration by drinking enough water while avoiding excessive fluid intake is important for kidney function.


  • Regular Exercise

It’s no surprise that regular physical activity benefits overall health, including kidney health. Try moderate-intensity exercises such as walking, swimming, or cycling to help maintain a healthy weight, manage blood pressure, and improve cardiovascular health, reducing the risk of CKD.

  •  Maintaining a Healthy Weight

Obesity and being overweight contribute to the development and progression of CKD. By maintaining a healthy weight through a combination of a balanced diet and regular exercise, individuals can reduce their risk of developing CKD and manage existing kidney conditions more effectively.

  •  Managing Underlying Medical Conditions

Controlling and managing underlying medical conditions such as diabetes and hypertension is essential in preventing or slowing the progression of CKD. Strict adherence to prescribed medications, regular medical check-ups, and lifestyle modifications can significantly reduce the risk of kidney damage associated with these conditions.

  •  Medication and Treatment Adherence

For individuals with CKD or other chronic conditions, following prescribed medications and treatment plans is crucial. Adherence to medication schedules, dietary restrictions, and lifestyle recommendations provided by healthcare professionals can help manage symptoms, slow disease progression, and improve overall kidney health.

  •  Regular Health Check-ups

Regular health check-ups are vital for early detection and management of CKD. Routine screenings of blood pressure, urine tests to check for proteinuria or hematuria, and kidney function tests (e.g., eGFR and creatinine levels) enable timely intervention and monitoring of kidney health.

  •  Avoiding Nephrotoxic Substances

Many toxic substances can be harmful to the kidneys and contribute to kidney damage. Avoiding or minimizing exposure to nephrotoxic substances such as certain medications (ask your doctor or pharmacist before discontinuing any over the counter or prescription meds), environmental toxins, and excessive use of non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen can help preserve kidney function.



Chronic Kidney Disease is a complex and widespread health condition with significant implications for people who suffer from it. By focusing on prevention strategies, raising awareness, and promoting early detection and management, the burden of CKD can be reduced.

Ongoing scientific research and advancements offer hope for improved diagnostic techniques, innovative treatments, and personalized approaches to kidney care.


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